Antibody Cusub Oo Si Adag U Dhexdhexaadiya Omicron iyo Kala duwanaanshiyaha

Written by editor

Sorrento Therapeutics, Inc. ayaa maanta ku dhawaaqday sii deynta xog cusub oo ku saabsan Omicron variant neutralizing antibody (nAb) STI-9167, COVISHIELD, oo ah unug heer sare ah oo ka hortag ah oo la helay loona sameeyay tijaabooyin caafimaad iyadoo iskaashi joogto ah uu dhexmaro dhakhaatiirta difaaca jirka iyo virologists ee Sorrento iyo Icahn Dugsiga Caafimaadka ee Mount Sinai ee New York, NY.

Print Friendly, PDF & Email

Qiimaynta xidhitaanka borotiinka ee Spike iyo tijaabooyinka dhexdhexaadinta iyadoo la adeegsanayo fayrasyo ​​matalaya dhammaan SARS-CoV-2 kala duwanaanshaha walaaca (VOCs) ayaa lagu dhammaystiray STI-9167, nAb-na waxaa loo arkay inuu ku xidho xidhiidh sare oo uu bixiyo waxqabad aad u awood badan oo dhexdhexaadin ah (Omicron IC50). = 25 ng/ml). Muhiimadda la xusay, STI-9167 waa mid gaar ah marka la barbar dhigo tijaabooyinka EUA-ansixisay SARS-CoV-2 nAbs ee ku-xidhka iyo ka-hortagga guryaha ayaa lagu ilaaliyaa kala duwanaanshaha Omicron iyo Omicron (+ R346K), oo ah nooc si isa soo taraya u faafay oo kala duwanaanshiyaha Omicron waxay dejinaysaa beddelaad borotiinka Spike R346K dheeraad ah. Intaa waxaa dheer, STI-9167 waxaa lagu maamulaa qiyaas yar (5mg/kg) iyada oo la adeegsanayo marinnada sanka ama xididdada dhiigga midkoodna waxay siisay difaac adag oo ka dhan ah calaamadaha caafimaad ee caabuqa ee kala duwanaanshaha Omicron ee qaabka K18-hAce2 transgenic mouse model ee COVID-19, ka hortagga miisaanka. lumin iyo hoos u dhigista tirooyinka fayraska ee sambabada ilaa heerar aan la ogaan karin.

"Jiilka iyo dabeecadda STI-9167 nAb waxay muujinaysaa iskaashiga weyn ee u dhexeeya saynisyahannada Mount Sinai iyo Sorrento si wax looga qabto dhibaatada caafimaad ee caalamiga ah," ayuu yiri Domenico Tortorella, PhD, Professor Microbiology at Icahn Mount Sinai.

"Waxaan ka dooranay kahortaga difaaca STI-9167 noocyo badan oo kala duwan oo ka hortag ah SARS-CoV-2 ee ka hortagga unugyada difaaca jirka ee aan ku soo saarnay shaybaaradayada. Waxay muujisay dhexdhexaadinta ugu waxtarka badan ee ka soo horjeeda dhammaan SARS-CoV-2 la yaqaan ee go'doominta iyo kala duwanaanta walaacyada, oo ay ku jiraan kala duwanaanshaha Omicron iyo Omicron (+ R346K) ee dhowaan, "ayuu yiri J. Andrew Duty, PhD, Kaaliyaha Professor ee Microbiology iyo Agaasimaha Xarunta Horumarinta Kahortagga Jirka ee Therapeutic ee Icahn Mount Sinai.

Mike A. Royal, MD, JD, MBA, Sarkaalka Sare ee Caafimaadka Sorrento. "Nabs beddelka ah ayaa si aad ah loogu baahan yahay xilliga dhow, gaar ahaan dadweynaha carruurta ee u muuqda inay halis sare ugu jiraan caabuqa omicron iyo isbitaal dhigista. Qaabka sanka ee COVIDROPS ee sanka ku jira waxa uu nAbs-keena geeyaa marinnada hawadu marto ee sare halkaas oo Omicron ay u badan tahay in lagu beegsado oo uu ku kobco, iyo sida aan fiicneyn, oo fudud in lagu maamulo, waxa ay ku habboon tahay carruurta. Waxaan mar hore bilownay inaan daweyno carruurta qaba COVIDROPS (oo leh STI-346) gudaha Mexico halkaas oo kala duwanaanshaha delta uu weli ku badan yahay. Iyada oo loo marayo daraasadaha wejiga 2099 ee US, United Kingdom iyo Mexico, waxaan ku aragnay muuqaal badbaado oo wanaagsan oo loogu talagalay dhalmada sanka ee sanka ee nAbs-yada waxaanan rajeyneynaa natiijo la mid ah COVIDROP (oo leh STI-2)."

"Waxaan hadda khibrad u lahayn keenista daawayn badan oo COVID-19 ah oo la geliyo rugta caafimaadka oo aan dhowr jeer u gudubno Wajiga 2 iyo/ama horumarka muhiimka ah," ayuu yiri Mark Brunswick, PhD, SVP iyo Madaxa Arrimaha Sharciyada iyo Tayada ee Sorrento. "Waxaan ku sugannahay inaan si degdeg ah ugu soo saarno COVISHIELD iyada oo loo marayo marxaladda IND iyo gudaha rugta caafimaadka waxaanan rajeyneynaa inaan buuxinno IND-gan muhiimka ah bisha soo socota."

Dr. Henry Ji, Gudoomiyaha iyo Maamulaha Sorrento, ayaa faallo ka bixiyay, "Shaqada ay qabteen kooxaha Sorrento iyo Mount Sinai waxay soo saareen ka hortag cajiib ah oo leh sifooyin ilaalin gaar ah oo qiimo leh oo liddi ku ah Omicron iyo dhammaan SARS-CoV-2 VOCs. Kahortagaha iska caabinta COVISHIELD waa kan ugu wanaagsan fasalka iyo musharaxa ugu horumarsan ee lagula dagaalamayo Omicron-ka baahsan iyo Omicron (+ R346K) VOCs. Waxaan si taxaddar leh uga shaqeyneynaa sidii aan u meel dhigi lahayn ka-hortagga ka-hortagga si loogu isticmaalo bukaannada COVID waxaanan ku kalsoonnahay in habkayagu uu bixin doono xal caafimaad oo wax ku ool ah ma ahan oo keliya xilliga dhow laakiin sidoo kale maaddaama masiibada ay sii socoto inay sii socoto."

Qoraal-gacmeedka preprint ayaa la gudbiyay Janaayo 19, 2022 waxaana lagu daabici doonaa wax yar onlayn biorxiv.org.

Ka-hortagga ka-hortagga ee lagu tilmaamay waxaa laga soo saaray shaybaarrada ku yaal Buurta Siinay oo si gaar ah shati loogu siiyay Sorrento Therapeutics. Xubnaha macalimiinta Mount Sinai iyo Mount Sinai waxay dan dhaqaale ka leeyihiin Therapeutics Sorrento.

Print Friendly, PDF & Email

War ku saabsan qoraaga

editor

Tifaftiraha madaxa eTurboNew waa Linda Hohnholz. Waxay ku salaysan tahay eTN HQ ee Honolulu, Hawaii.

Leave a Comment