Tijaabo Caafimaad oo Cusub oo loogu talagalay Daawaynta Kansarka qanjirka 'prostate'

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Hinova Pharmaceuticals Inc., oo ah shirkad heer-caafimaad biopharmaceutical ah oo diiradda saarey horumarinta daaweynta cusub ee kansarrada iyo cudurrada dheef-shiid kiimikaadka iyada oo loo marayo tignoolajiyada burburinta borotiinka, ayaa ku dhawaaqday in bukaankii ugu horreeyay ee qaba kansarka qanjirka 'prostate-u adkeysiga dheef-shiid kiimikaadka' Tijaabada caafimaad ee HP518, aad loo xushay oo afka laga heli karo kimeric degrader oo bartilmaameedsanaysa soo-dhowaynta androgen (AR). Summada furan ee socota ee Wajiga I ee Australia waxay qiimeyn doontaa badbaadada, farmashiyaha, iyo waxqabadka ka hortagga burada ee HP518 ee bukaannada qaba mCRPC.

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HP518 waxa la helay oo soo saartay Hinova bartilmaansaneed ee burburinta borotiinka madal daahfurka daroogada. Waxay awood u leedahay inay ka gudubto iska caabbinta daawada kansarka qanjirka 'prostate' sababtoo ah isbeddellada AR ee gaarka ah.

Degraders Chimeric waa unugyo yaryar oo laba-shaqeeya kuwaas oo kor u qaada hoos u dhaca borotiinada bartilmaameedka leh ee leh awood sare iyo xulashada sare. Tignoolajiyadani waxay awood u leedahay inay beegsato bartilmaameedyada aan dawada lahayn iyo inay ka gudubto arrinta iska caabbinta daroogada ee dawooyinka molecule-yar ee dhaqameed.

"Tani waa guul muhiim ah oo laga gaaray horumarka dadaalkeena laga soo bilaabo baarista daroogada ilaa daraasadda bukaan-socodka," ayuu yiri Yuanwei Chen, Ph.D., Madaxweynaha iyo Maamulaha Hinova. "Waan ku faraxsanahay arrintaas waxaana u heellan inaan u keeno doorashooyin cusub oo daweyn bukaannada adduunka oo dhan!"

Iyada oo loo marayo goobta lagu helayo dawada baabi'isa borotiinka, Hinova waxay si degdeg ah u eegi kartaa nashaadaynta borotiinka waxayna ku guulaysan kartaa naqshad hufan iyo hagaajinta kuwa wax-jabiya chimeric. Intaa waxaa dheer, Hinova waxay khibrad qoto dheer u leedahay xakamaynta soo saarista kiimikaad ee xeryahooda degrader.

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War ku saabsan qoraaga

editor

Tifaftiraha madaxa eTurboNew waa Linda Hohnholz. Waxay ku salaysan tahay eTN HQ ee Honolulu, Hawaii.

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