DHIBAATOOYINKA
Gudbinta SARS-CoV-2 ee ugu sarreysa ayaa ka socota Chile in kasta oo olole tallaal oo xoog leh, kaas oo inta badan ku tiirsan tallaalka fayraska aan firfircoonayn ee Sinovac Biotech iyo in yar oo ka mid ah tallaalka mRNA ee Pfizer/BioNTech iyo tallaallada fayraska fayraska ee aan tarmin Oxford/AstraZeneca iyo Cansino Biologicals.
Qalliinkii ugu dambeeyay ee laga soo sheegay dalka waxaa gacanta ku haayay noocyada SARS-CoV-2 ee Gamma iyo Lambda, kii hore ee lagu sifeeyay kala duwanaanshiyaha walaac dhowr bilood ka hor kan dambena waxaa dhawaan loo aqoonsaday inuu yahay nooc dano ay leedahay WHO. In kasta oo kala duwanaanshaha Gamma uu leeyahay 11 beddelaad oo borotiinka sare ah oo ay ku jiraan kuwa ku jira domain-ku-xidhidhiyaha (RBD) ee la xidhiidha kororka ACE2 xidhitaanka iyo caabuqa (N501Y) ama badbaadada difaaca (K417T iyo E484K) borotiinka sare ee kala duwanaanshaha Lambda wuxuu leeyahay mid gaar ah. qaabka 7 isbeddellada (Δ246-252, G75V, T76I, L452Q, F490S, D614G, T859N) kaas oo L452Q uu la mid yahay isbeddelka L452R ee laga soo sheegay noocyada Delta iyo Epsilon.
Isbeddelka L452R ayaa la muujiyey inuu siinayo baxsashada difaaca jirka unugyada difaaca jirka (mAbs) iyo sidoo kale plasma convalescent.
Intaa waxaa dheer, is -beddelka L452R ayaa sidoo kale la muujiyey inuu kordhiyo caabuqa fayraska xogtayadu waxay soo jeedinaysaa in is -beddelka L452Q ee ku jira kala duwanaanshaha Lambda laga yaabo inuu siiyo hanti la mid ah kuwa lagu tilmaamay L452R. Waxa xiisaha lihi leh, tirtiridda 246-252 ee aagga N-terminal (NTD) ee Lambda Spike wuxuu ku yaal meel sare oo antigenic ah sidaa darteedna, tirtiriddan ayaa waliba gacan ka geysan karta baxsashada difaaca. Intaa waxaa dheer, is -beddelka F490S ayaa sidoo kale lala xiriiriyay u baxsashada sera isku -dhafan.
Iyadoo la raacayo waxyaabahan hore, natiijooyinkayagu waxay tilmaamayaan in borotiinka kororka ee kala duwanaanshaha Lambda uu u oggolaanayo baxsasho difaac si looga takhaluso unugyada difaaca ee uu keenay tallaalka CoronaVac. Haddii kala duwanaanshaha Lambda uu sidoo kale u baxsado jawaabta gacanta oo ay muujisay inay ka timid CoronaVac weli lama yaqaan.
Waxaan sidoo kale aragnay in borotiinka kororka ee kala duwanaanshaha Lambda uu soo bandhigay caabuq kordhay marka la barbar dhigo borotiinka kororka ee kala duwanaanshaha Alpha iyo Gamma, labadoodaba waxaa la soo sheegay inay sii kordheen faafidda iyo gudbinta.
Wadajir ahaan, xogtayadu waxay muujineysaa markii ugu horreysay in is -beddellada ku jira borotiinka kororka ee kala duwanaanshaha Lambda ay bixiyaan baxsad si looga takhaluso unugyada difaaca jirka iyo kordhinta faafitaanka. Caddaynta halkan lagu soo bandhigay waxay xoojinaysaa fikradda ah in ololeyaal tallaal oo ballaaran laga sameeyo waddammada leh heerarka wareegga SARS-CoV-2 oo sarreeya waa inay la socdaan ilaalin hidda-wadayaal ah oo looga golleeyahay in si dhakhso leh loo garto go'doominta fayraska cusub ee sidda is-beddellada dillaaca iyo sidoo kale daraasadaha loogu talagalay in lagu falanqeeyo saamaynta kuwan Isbeddellada baxsashada difaaca iyo tallaallada ayaa horumar gaara.
COVID-19 si dhakhso leh ayuu u socdaa. Tan waxaa lagu arki karaa Hawaii halkaas oo tirooyinku ay hooseeyeen oo u boodeen si ay u diiwaangeliyaan meel sare iyadoo dalxiisku aad u korayo.
