"Plaque psoriasis waxay culeys weyn saari kartaa nolosha bukaanka, iyadoon loo eegin darnaanta ku lug lahaanshaha maqaarka. Baahi la taaban karo oo aan la daboolin ayaa weli u ah bukaannada cudurka psoriasis ee fudud ama dhexdhexaad ah kuwaas oo daawaynta la mariyo laga yaabo inaysan ku filnayn, gaar ahaan kuwa meelaha ay adag tahay in la daweeyo, sida maqaarka madaxa," ayuu yiri David M. Reese, MD, kuxigeenka fulinta ee cilmi-baarista. iyo Horumarinta Amgen. "Iyada oo tilmaantan la balaariyay ee Otezla, bukaannada dhammaan heerarka kala duwan ee darnaanta cudurrada hadda waxay leeyihiin ikhtiyaar afka ah, hab nidaamsan oo ay horay u isticmaaleen in ka badan 650,000 oo qof oo adduunka oo dhan ah oo aan lahayn wax shuruud ah oo la socodka shaybaarka."
"Marka la eego in cudurka psoriasis uu yahay cudur barar ah oo nidaamsan, bukaannada qaar ayaa laga yaabaa inay u baahdaan wax ka badan gargaarka heerka dusha sare," ayay tiri Dr. Linda Stein Gold, maamulaha Cilmi-baarista Kiliinikada maqaarka ee Nidaamka Caafimaadka Henry Ford, Detroit, iyo baaraha ADVANCE. "Markii ugu horeysay, dhakhaatiirta maqaarku waxay siin karaan bukaanada la halgamaya cudurka psoriasis ee shahaado kasta oo daaweyn afka ah oo wax ku ool ah oo leh astaanta badbaadada."
Oggolaanshaha FDA waxay ku salaysan tahay natiijooyinka ka soo baxa tijaabada 3 ADVANCE, kaas oo shan jeer in ka badan dadka qaangaarka ah ee qaba cudurka psoriasis khafiif ah ama dhexdhexaad ah oo qaata Otezla 30 mg laba jeer maalintiiba waxay heleen dhamaadka aasaasiga ah ee jawaabta Qiimaynta Caalamiga ah ee Dhakhaatiirta Static (sPGA) ee usbuuca 16 marka la barbar dhigo placebo (21.6% oo ka soo horjeeda 4.1%, p<0.0001), farqi weyn oo tirakoob ahaan ahaa. Otezla waxa kale oo ay muujisay horumarro la taaban karo oo xagga tira-koobka ah ee calaamadaha muhiimka ah, sida Jawaabta Cuncunka Jirka oo dhan ee NRS (43.2% oo ka soo horjeeda 18.6%), iyo meel ay adag tahay in lagu daweeyo, madaxa, oo lagu cabbiray jawaabta Qiimaynta Caalamiga ah ee Dhakhaatiirta Scalp (ScPGA) (44% marka loo eego 16.6%), usbuuca 16 marka la barbar dhigo placebo. Hagaajinta jawaabta sPGA, Jirka oo dhan cuncun NRS iyo jawaabta ScPGA ayaa la arkay horaantii usbuuca 2 waxaana la sii waday ilaa usbuuca 32.
Dhacdooyinka xunxun ee lagu arkay tijaabada waxay la socdeen astaanta badbaadada ee Otezla. Inta badan la soo sheego (≥5%) daawaynta degdega ah ee daawaynta Otezla waxay ahaayeen shuban, madax-xanuun, lallabbo iyo nasopharyngitis.
Ku dhawaad 8 milyan oo qof oo Maraykan ah ayaa qaba cudurka psoriasis huurada, iyo 5 milyan oo qof oo Maraykanka ku nool ayaa qaba cudur fudud ama dhexdhexaad ah. In kasta oo fiditaanka iyo daawaynta horumartay sannadihii u dambeeyay, baahi weyn oo aan la daboolin ayaa weli ah, gaar ahaan dadka qaba cudurka psoriasis fudud ama dhexdhexaad ah ama kuwa la kulma calaamado joogto ah in kasta oo daawaynta jirka la mariyo.
"Plaque psoriasis inta badan waxay u saamaysaa bukaanka si aad u daran marka loo eego Aagga Dusha Jirka oo keliya, gaar ahaan kuwa leh muuqaalada meelaha ay adag tahay in lagu daweeyo sida madaxa. Meesha tabeelooyinku waxay ka dhigi kartaa aagga mid xasaasi u ah daawaynta la mariyo ama ay ku adkaato in lagu dabaqo,”2 ayay tiri Stacie Bell, Ph.D., sarkaalka sare ee sayniska iyo caafimaadka ee National Psoriasis Foundation. "Waa war soo dhaweyn leh in ugu dambeyntii la helo ikhtiyaarka habka afka ah oo leh astaan badbaado oo si wanaagsan loo aasaasay oo ay heli karaan dhammaan bukaannada cudurka psoriasis ee qaangaarka ah."
Otezla waxaa loo oggolaaday saddex tilmaame gudaha Mareykanka, oo ay ku jiraan bukaanada qaangaarka ah ee qaba cudurka psoriasis ee u sharaxan daaweynta sawir-qaadista ama daaweynta nidaamka, bukaannada qaangaarka ah ee qaba cudurka psoriasis ee firfircoon iyo bukaannada qaangaarka ah ee qaba boogaha afka ee la xiriira Cudurka Behcet. Otezla waa calaamadda ugu badan ee loogu talagalay bukaannada cudurka psoriasis ee plaque ee bilaabaya daaweynta nidaamka.3 Amgen waxaa ka go'an in ay baaraan kartida Otezla ee guud ahaan cudurka psoriasis, oo ay ku jiraan bukaanada aan la daboolin ee cudurka psoriasis xubinta taranka, cudurka psoriasis ee carruurta, arthritis-ka psoriatic ee carruurta iyo meelaha kale ee culeyska sare leh.
